![]() ![]() These valves are formed from tissue folds that open and close by dilation and contraction of the heart. Tissue engineering of heart valves - current aspects, Thorac. Blood flow is kept unidirectional through a series of valves or cusps. Porcine Small Intestinal Sub-Mucosa Bioscaffold Valve for Pediatric Mitral Valve. decellularized scaffold, polymer-based scaffold, nanoscaffold and nanocomposite scaffold and scaffold material modification. The creation of tissue-engineered heart valves starts from the decellularised or synthetic scaffold, which represents the basic platform where cells proliferate. Introduction As a primary organ, the heart is fundamentally a two-sided pump responsible for maintaining blood flow throughout the body. ![]() Here, we reviewed the scaffold materials previously used in TEHV, e.g. The goal of the present study was to design a bioresorbable synthetic heart valve that can maintain long-term functionality as a pulmonary valve in sheep, recruit host cells, and support the in situ formation of neo-tissue by these cells in pace with scaffold resorption. Hence, clinical efforts should be made to remodel the scaffold materials, allowing for utilizing its functionalization. To produce a fully functional heart valve using tissue engineering, an appropriate scaffold needs to be seeded using carefully selected cells and proliferated under conditions that resemble the environment of a natural human heart valve. However, no such valve scaffold is currently available. Tissue engineering is a new, emerging alternative, which is reviewed in this paper. A desirable valvular scaffold, which mimics the three-dimensional ultrastructures of extracellular matrix (ECM) in the heart valve, should possess the ECM bioactivity, favorable tissue compatibility and suitable mechanical properties. A foundation for success in heart valve tissue engineering is a recapitulation of the complex design and diverse mechanical. A substantial number of studies suggested that the TEHV available at present has insufficient mechanical properties and lacks relevant anti-calcification function, both of which prevent the successful application of TEHV into clinical practice. In the paradigm of tissue engineering, a three-dimensional platform the so-called scaffold is essential for cell proliferation, growth and differentiation, as well as the ultimate generation of a functional tissue. As a result of the specific position and function of a specific heart valve, significantly high requirements of mechanical and biological properties are necessary for optimal function. The foundation of successful heart valve tissue engineering is replicating native heart valve architecture, mechanics, and cellular attributes through appropriate biomaterials and scaffold designs. Theoretically, TEHV has good tissue compatibility, self-repair potential and life-long durability, which serves as the optimal replacement for a heart valve. Tissue engineered heart valve (TEHV) is a valve replacement of scaffold materials on which live cells grow. ![]()
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